Last Updated on July 16, 2026 by Dr. Bhagat
Journal Profiles·Updated June 2026
CA: A Cancer Journal for Clinicians Impact Factor (685.2)
A 2025 Impact Factor of 685.2 isn’t a typo — here’s the publishing model behind the world’s number-one journal, and why it dwarfs even Nature and The Lancet.
MechanicsWhy CA Has the World’s Highest Impact Factor
The number looks impossible until you remember how the Impact Factor is calculated: total citations in a year to the previous two years’ articles, divided by the number of those articles.
CA publishes very few articles, and the ones it does publish — above all the annual Cancer Statistics review — are cited thousands of times across oncology. A tiny denominator beneath an enormous citation numerator produces a score in the hundreds.
This is the clearest real-world demonstration of why the Impact Factor rewards citation density, not volume. A journal that publishes a handful of field-defining reviews can mathematically outscore one publishing thousands of solid research articles.
World rankingHow It Compares to the Other Giants
Even among the most prestigious journals on earth, CA stands alone — its Impact Factor is several times that of the next titles on the global list:
| Journal | 2025 Impact Factor |
|---|---|
| CA: A Cancer Journal for Clinicians | 685.2 |
| Nature Reviews Molecular Cell Biology | 118.0 |
| The Lancet | 109.0 |
| Nature Reviews Microbiology | 104.6 |
| Nature Reviews Clinical Oncology | 94.6 |
| New England Journal of Medicine | 84.5 |
Source: Journal Citation Reports 2025 (Clarivate)
BenchmarkWhy CA Is a Poor Benchmark for Ordinary Journals
Because its score is driven by a unique publishing model, CA should never be used as a yardstick for “normal” journals. A 5-10 Impact Factor is excellent in most fields. Comparing an ordinary research journal to CA is meaningless.
OncologyQuartile and Category Standing
In the Oncology category, CA sits comfortably in the top tier (Q1). It is indexed in the Science Citation Index Expanded (SCIE) within Web of Science, which is the collection that feeds the Journal Impact Factor.
Scope & accessShould You Submit to CA?
For most researchers, CA is not a typical submission target. It publishes authoritative, largely commissioned reviews and statistical reports aimed at clinicians, rather than unsolicited primary research. If you work in cancer epidemiology or clinical oncology, the realistic path is to read and cite it; original research usually belongs in specialist oncology journals.
Confirm current scope and author guidelines on the official journal site before considering a submission. CA’s editorial policy may change over time.
At a glanceKey Facts
| Field | Detail |
|---|---|
| Full title | CA: A Cancer Journal for Clinicians |
| Publisher | American Cancer Society (published with Wiley) |
| ISSN / eISSN | 0007-9235 / 1542-4863 |
| Web of Science category | Oncology |
| Index | SCIE (Web of Science) |
| 2025 Impact Factor | 685.2 |
| Quartile | Q1 |
| Total citations | 78,841 |
| Best known for | Annual Cancer Statistics report & clinical guideline reviews |
Source: Journal Citation Reports 2025 (Clarivate). For Scopus-based metrics (CiteScore, SJR), check Scopus and SCImago — they are reported separately.
Key Takeaways
FAQPeople also ask
What is the highest impact factor journal in the world?
CA: A Cancer Journal for Clinicians, with a 2025 Journal Impact Factor of 685.2 (JCR, Clarivate). It has held the world’s number-one position for years.
Why is CA’s impact factor so high?
Because it publishes very few articles, and those it publishes — especially the annual Cancer Statistics review — are cited enormously. A small denominator with a huge citation count yields a score in the hundreds.
Who publishes CA: A Cancer Journal for Clinicians?
It is published by the American Cancer Society, in partnership with Wiley. It is an authoritative clinical-oncology journal aimed primarily at practising clinicians.
Can I submit my research to CA?
Generally not in the usual way — CA publishes mostly commissioned reviews and statistical reports rather than unsolicited primary research. Most original cancer research is better directed to specialist oncology journals.
Does a high impact factor always mean a better journal?
No. The Impact Factor measures average citations, not quality or fit, and it varies hugely by field. A 5-10 Impact Factor is excellent in most disciplines. The best journal for your paper is the one with the right scope, audience, and legitimate indexing.
SourcesReferences & further reading
SEO & Publishing Data
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ContextWhy CA’s Impact Factor Is So Extraordinarily High
CA’s Impact Factor of 685.2 is not typical of medical journals. It results from a unique publishing model. The journal publishes only about 20-30 articles per year, but many are the highly-cited Cancer Statistics annual reports, which routinely accumulate thousands of citations. With so few articles in the denominator and massive citation counts in the numerator, the ratio becomes exceptionally large.
By comparison, Nature publishes thousands of articles annually, spreading its citations across a much larger base. CA is therefore not directly comparable to general research journals — it operates in a category of its own.
Pro TipsHow to Interpret CA’s Metrics as a Researcher
1. Do not target CA for routine submissions. CA publishes review articles and statistical reports by invitation only. Original research submissions are not accepted.
2. Cite CA articles where relevant. The Cancer Statistics reports are authoritative sources for epidemiological data and are expected citations in oncology research.
3. Use CA to understand citation dynamics. The journal demonstrates how publishing models affect metrics. A small, highly-cited article set produces very different numbers than a large, general-interest journal.
4. Compare within categories. When evaluating oncology journals, compare CA against Journal of Clinical Oncology or The Lancet Oncology for a fairer benchmark.
FAQFrequently Asked Questions
Is CA: A Cancer Journal for Clinicians a predatory journal?
No. CA is published by the American Cancer Society in partnership with Wiley. It is one of the most respected and longest-running oncology review journals, established in 1950.
Can I submit my research to CA?
CA does not accept unsolicited original research. It publishes review articles, statistical reports, and special features by editorial invitation only.
Why is CA’s Impact Factor higher than Nature and Science combined?
Because CA publishes very few articles (approximately 20-30 per year), and many are the Cancer Statistics reports that accumulate thousands of citations. The Impact Factor is a ratio of citations to articles — with a tiny denominator, the ratio becomes very large.
What is the acceptance rate for CA?
The acceptance rate is extremely low, estimated at under 5%. Most content is commissioned by the editorial board rather than submitted through regular channels.
Is CA indexed in Scopus and PubMed?
Yes, CA is indexed in Scopus, PubMed/MEDLINE, and the Web of Science Core Collection. It is also ranked Q1 in Oncology by all major indexing services.
Sources
- CA: A Cancer Journal for Clinicians — Official Website
- Clarivate Journal Citation Reports (JCR) 2025
- American Cancer Society — cancer.org